Pharmacology The University of Manchester

Overview

About the programme

The Pharmacology course from The University of Manchester research focuses on a range of topics. These include:

• the pharmacology of drug efflux transporters, particularly ABCB1 P-glycoprotein, ABCG2 breast cancer resistance protein and ABCC multidrug resistance-associated transporters;
• developing complex, physiologically-relevant in vitro cell systems to investigate transport, metabolism and delivery of therapeutic drugs;
• understanding the pharmacological and molecular mechanisms that regulate expression and function of drug efflux transporters, particularly in the blood-brain barrier;
• the role of blood-brain barrier drug efflux transporters in drug delivery to the central nervous system and the effects of inflammatory and degenerative conditions, eg Alzheimer's disease, on efflux transporter function;
• the biological role of lipid networks in health and disease, particularly their roles in inflammation, cellular communications and tissue responses;
• employing mass spectrometry-based lipidomic technology, in conjunction with functional, metabolic and signaling approaches to characterise lipid profiles in physiological and pathophysiological conditions;
• investigating the role of lipids in skin homeostasis and in response to inflammation, injury and wound healing;
• studying role of local hormones in diseases and conditions associated with the female reproductive tract (eg dysmenorrhoea, endometriosis and the detection and prevention of preterm labour);
• molecularly identifying and pharmacologically characterising receptors expressed in the female reproductive system;
• understanding the physiological and pharmacological characteristics of the placenta. These studies include the development of placental homing peptide-microRNA inhibitor conjugates for targeted enhancement of placental growth signaling.